Open AccessIn vitro drug susceptibility pattern of Mycobacterium tuberculosis in CAT I and CAT II pulmonary tuberculosis patients in Aligarh, Uttar Pradesh, India
Author(s) -
Sumit Kumar Varshney,
Indu Shukla,
Adil Raza,
Zuber Ahmad
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60697-6
Subject(s) - ethambutol , rifampicin , isoniazid , streptomycin , medicine , tuberculosis , mycobacterium tuberculosis , drug resistance , capreomycin , multiple drug resistance , microbiology and biotechnology , veterinary medicine , antibiotics , pathology , biology
Objective: To evaluate in vitro resistance pattern of the first line anti-tubercular drugs in new\udand previously treated cases of pulmonary tuberculosis patients in Aligarh region.\udMethods: This study was carried out involving 975 suspected tuberculosis patients. All the\udspecimens of patients were subjected to Ziehl-Neelsen staining, cultured on Lowenstein-Jensen\udmedium and resistance pattern was evaluated by standard proportion method. All patients\uddiagnosed with pulmonary tuberculosis were placed in CAT I and II under Revised National\udTuberculosis Control Programme guidelines.\udResult: Out of 220 patients, 129 (58.7%) were from CAT I and 91 (41.3%) were from CAT II. Totally\ud44.5% were resistant to one or more than two drugs and 18.6% patients showed resistance to both\udisoniazid and rifampicin. The individual resistance pattern of these first line drugs were as\udfollows: 37.7% patients were resistant to isoniazid, 22.2% to rifampicin, 8.6% to streptomycin and\ud10% were resistant to ethambutol.\udConclusions: Our findings concluded a high prevalence of in vitro drug resistance of\udMycobacterium tuberculosis isolates, especially multidrug resistant tuberculosis, in both the\udcategories. So there is an urgent need to further study the risk factors for transmission and\udmultidrug resistant tuberculosis in these settings