Open AccessSurveillance of tuberculosis co-infection among HIV infected patients and their CD4+ cell count profile
Author(s) -
Shraddha Jain,
Amit Kumar Singh,
Ravinder Pal Singh,
Jyoti Bajaj,
Ajit Damle
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60660-5
Subject(s) - medicine , tuberculosis , sputum , mycobacterium tuberculosis , human immunodeficiency virus (hiv) , immunology , pathology
Objective: To determine the occurrence of tuberculosis (TB) among HIV infected patients and\udtheir CD4+ cell count profile.\udMethods: A total of 263 HIV-seropositive patients either hospitalized or reporting to the antiretroviral therapy centre for follow up were included in the study. HIV-seropositive patients were\udthen investigated clinically, radiologically and microbiologically for diagnosis of pulmonary TB\udas per the revised guidelines issued by WHO. Two early morning sputum samples were collected\udfrom patients, and isolation and identification of Mycobacterium tuberculosis was done as per\udstandard protocol.\udResults: Out of them 41 (15.6%) were TB positive and 222 (84.4%) were TB negative. Among TB\udpositive patients, smear positive and culture positive patients were 19 (7.2%), while smear negative\udand culture positive were 9 (3.4%). Mean CD4+ T cell counts for HIV-seropositive and HIV-related\udTB patients were 156.14 cells/µL and 197.24 cells/µL respectively.\udConclusions: The clinical manifestations in HIV-related TB patients are quite variable and lead\udto difficulties in diagnosis. Thus radiological evaluation along with proper laboratory investigation\udin all clinically suspected cases of tuberculosis is the key for prompt diagnosis and treatment