Open AccessHypoglycemic activity of methanolic leaf extract of Blumea lacera in Swiss-albino mice
Author(s) -
Md. Nazmul Hasan,
Mohammad Habibur Rahman,
Ruiyun Guo,
Akinori Hirashima
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60652-6
Subject(s) - glibenclamide , traditional medicine , medicine , diabetes mellitus , chemistry , endocrinology
Objective: To estimate the hypoglycemic activity of Blumea lacera (B. lacera) leaf methanol\udextract.\udMethods: A study was undertaken for preliminary exploration of hypoglycemic activity via\udoral glucose tolerance test. B. lacera leaves were dried under shaded sunlight, milled and then\udmacerated in methanol. Glibenclamide was used as reference drug, and 50-400 mg/kg leaf extract\udwas administered orally to four test groups.\udResults: Treatment of leaf extract on glucose loaded hypoglycemic mice lead to significant\ud(P<0.000 1) reduction of the blood glucose levels in a dose dependent manner.\udConclusions: The result suggests that methanolic leaf extract of B. lacera possesses antidiabetic properties, and its use as ethnomedicine for treatment of diabetes