Open AccessKiller cell immunoglobulin like receptors gene polymorphism in patients with dengue infection, Andaman Islands, India
Author(s) -
R. Thamizhmani,
Chaaithanya Itta Krishna,
Sugunan Attayur Purushottaman,
Paluru Vijayachari
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60625-3
Subject(s) - dengue fever , antibody , receptor , gene , immunology , virology , polymorphism (computer science) , biology , genotype , genetics
Objective: To identify the possible association of killer cell immunoglobulin like receptors (KIRs)\udgene polymorphisms in patients with dengue virus infection.\udMethods: Seventeen known KIRs were determined in 30 dengue patients and 40 healthy\udindividuals by the sequence specific primer polymerase chain reaction method. Associations\udwith specific KIR genes were tested using the Chi-squared test and Fisher test using EpiInfo 7\udsoftware.\udResults: All frame work genes and pseudo genes were detected among 97% and 98% of all dengue\udcases and healthy individuals respectively. The total carriage frequency of KIR3DL1 and KIR2DL2\udwere decrease in dengue patients compared with healthy individuals (P=0.000 0 and P=0.000 5\udrespectively) from A haplotype and inhibitory receptors.\udConclusions: The KIR polymorphisms may be associated with susceptibility to dengue virus\udinfection. It could be suggested that KIR3DL1 and KIR2DL2 were susceptibility genes for dengue\udvirus. However, these findings provide certain support for hypothesis, that KIR genes influence\udsusceptibility and may play a role in the clearance of dengue virus infection