Open AccessA possible clinical benefit of the identification and characterization of colon cancer stem cells
Author(s) -
Maria Toloudi,
Panagiotis Apostolou,
Marina Chatziioannou,
Eleni Kourtidou,
Ioanna Vlachou,
Mimikakou Georgia,
Ioannis Papasotiriou
Publication year - 2015
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60621-6
Subject(s) - homeobox protein nanog , sox2 , colorectal cancer , cancer stem cell , stem cell , cancer , medicine , cancer research , population , oncology , side population , pathology , gene , biology , embryonic stem cell , induced pluripotent stem cell , genetics , environmental health
Objective: To assess the existence of colon cancer stem cells in different disease stages and\udidentify a possible correlation between this cell population and cancer progression.\udMethods: To investigate the correlation between nanog, oct3/4, sox2, and cd26 expression levels\udand colon carcinoma, a series of colon cancers were successfully analyzed, and various protocols\udwere performed on a group of patients. Peripheral blood was collected from six patients diagnosed\udwith various stages of colon carcinoma.\udResults: A potential gene expression pattern in colon carcinomas was observed.\udConclusions: This study focused on determining the associated molecular mechanisms, which\udcould be targeted to prevent and/or to minimize colon cancer’s side effects. It was found that\udcolon cancer stem cells existed in all clinical cases. A correlation between nanog, oct3/4, cd26\udand sox2 gene was also observed