Open AccessImmunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay
Author(s) -
Annie George,
Sasikala Chinnappan,
Yogendra Kumar Choudhary,
Praveen Bommu,
Murthy Sridhar
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60594-6
Subject(s) - levamisole , chemistry , phagocytosis , aqueous solution , polygonum , body weight , pharmacology , mononuclear phagocyte system , in vivo , aqueous extract , traditional medicine , immunology , endocrinology , medicine , biology , organic chemistry , microbiology and biotechnology
Objective: To explore the immunomodulatory properties of aqueous extract of Polygonum minus\udHuds (P. minus), on swiss albino mice using carbon clearance assay.\udMethods: The study was performed using in-vivo carbon clearance assay or phagocytosis.\udAqueous extract of P. minus was administered by oral route to Swiss albino mice for seven days.\udLevamisole, 2.5 mg/kg was used as standard drug.\udResults: The phagocytic function of reticuloendothelial system was significantly (P<0.05)\udenhanced by levamisole and P. minus aqueous extract groups compared to the control. Treatment\udwith aqueous extract of P. minus at 200 and 400 mg/kg body weight resulted in dose dependent\udincrease in phagocytic index (K) where phagocytic index of aqueous extract of P. minus at 400\udmg/kg body weight is comparable to the standard drug Levamisole at 2.5 mg/kg body weight.\udConclusions: Aqueous extract of P. minus has exhibited significant increase in phagocytosis at\uddoses of 200 mg/kg body weight and 400 mg/kg body weight