Open AccessHarnessing the medicinal properties of Andrographis paniculata for diseases and beyond: a review of its phytochemistry and pharmacology
Author(s) -
Agbonlahor Okhuarobo,
Joyce Ehizogie Falodun,
Osayemwenre Erharuyi,
Vincent Imieje,
Abiodun Falodun,
Peter Langer
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60509-0
Subject(s) - phytochemistry , andrographis paniculata , traditional medicine , acanthaceae , andrographolide , medicinal plants , biology , toxicity , amodiaquine , phytomedicine , pharmacology , medicine , malaria , plasmodium falciparum , immunology , alternative medicine , pathology
Andrographis paniculata Wall (family Acanthaceae) is one of the most popular medicinal plants\udused traditionally for the treatment of array of diseases such as cancer, diabetes, high blood\udpressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery,\uddyspepsia and malaria for centuries in Asia, America and Africa continents. It possesses several\udphotochemical constituents with unique and interesting biological properties. This review\uddescribes the past and present state of research on Andrographis paniculata with respect to the\udmedicinal usage, phytochemistry, pharmacological activities, toxicity profile and therapeutic\udusage, in order to bridge the gap requiring future research opportunities. This review is based on\udliterature study on scientific journals and books from library and electronic sources. Diterpenes,\udflavonoids, xanthones, noriridoides and other miscellaneous compounds have been isolated\udfrom the plant. Extract and pure compounds of the plant have been reported for their antimicrobial, cytotoxicity, anti-protozoan, anti-inflammatory, anti-oxidant, immunostimulant,\udanti-diabetic, anti-infective, anti-angiogenic, hepato-renal protective, sex hormone/sexual\udfunction modulation, liver enzymes modulation insecticidal and toxicity activities. The results of\udnumerous toxicity evaluations of extracts and metabolites isolated from this plant did not show\udany significant acute toxicity in experimental animals. Detailed and more comprehensive toxicity\udprofile on mammalian tissues and organs is needed in future studies