Open AccessImmunostimulant activity of Phyllanthus reticulatus Poir: a useful plant for infectious tropical diseases
Author(s) -
Sunil Kumar,
Shalini Sharma,
Dinesh Kumar,
Karunesh Kumar,
Renu Arya
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60496-5
Subject(s) - immunostimulant , levamisole , pharmacology , cyclophosphamide , traditional medicine , oral administration , immune system , biology , immunology , medicine , chemotherapy
Objective: To confirm the ethnomedicinal claim of Phyllanthus reticulatus Poir as immune\udenhancer.\udMethods: The hydroalcoholic extract of fruits and leaves of the plant were evaluated for\udimmunostimulant activity on albino mice at the dose levels of 1 00 and 200 mg/kg orally.\udThe assessment of immunostimulant activity on specific and non-specific immunity was\udstudied by neutrophil adhesion test, carbon clearance test and cyclophosphamide induced\udmyelosuppression. Cyclophosphamide (30 mg/kg) was used to induce immunosuppresion in mice\udand levamisole (50 mg/kg) was used as immunostimulating agent.\udResults: Oral administration of both the doses of fruit and leaf extracts showed significant\udincrease in phagocytic activity (***P<0.001) and the percentage of neutrophil adhesion (**P<0.01).\udSignificant increase in white blood cell (*P<0.05, **P<0.01) count was seen on administration of\udboth the doses of fruits and leaves extracts.\udConclusions: The study demonstrates that both the plant parts triggers specific and non-specific\udresponses and thus reveals a promise to hold immunostimulant activity