Prognostic implications of ischemia modified albumin in known cases of 86 elderly hypertensive South Asian aged 56–64 years – a hospital based study

Objective: To study associated ischemia modified albumin in hypertensive participants and to\udcompare the results with normotensive healthy controls.\udMethods: A total of 86 hypertensive patients and 86 age-sex matched normotensive healthy\udvolunteers were selected for this study. The study was conducted for a period of 3 years from\udSeptember 2007 to August 2010. Biochemical parameters and other parameters such as smoking\udhabits, systolic and diastolic blood pressure and family history were recorded. Lipid profile,\udischemia modified albumin, malondialdehyde and conjugated diene were measured by standard\udmethods and results were compared between patients and controls.\udResults: Total cholesterol, triglycerides, low density lipoprotein cholesterol were significantly\udhigher (P<0.001 ) in hypertensive subjects when compared to normotensive control. Also,\udsignificant differences were seen in high density lipoprotein cholesterol levels between both\udgroups (P<0.001 ). The index of lipid per oxidation comprising both malondialdehyde and\udconjugated dienes were significantly higher in hypertensive compared to normotensive controls.\udIschemia modified albumin levels were significantly increased among hypertensive compared to\udnormotensive controls (P<0.001).\udConclusions: Hypertensive patients have increased oxidative stress and are accompanied\udwith rise in ischemia modified albumin. Ischemia modified albumin could be incorporated as a\uddiagnostic test parameter in hypertensive to avoid the future acute coronary complications