Open AccessSerum biochemical responses under oxidative stress of aspartame in wistar albino rats
Author(s) -
Arbind Kumar Choudhary,
Rathinasamy Sheela Devi
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60478-3
Subject(s) - aspartame , antioxidant , lipid peroxidation , oxidative stress , chemistry , lipid profile , medicine , endocrinology , kidney , biochemistry , cholesterol
Objective: To study whether the oral administration of aspartame (40 mg/kg body weight) for 15\udd, 30 d and 90 d have any effect on marker enzymes, some selective liver and kidney function\udparameter, lipid peroxidation and antioxidant status in serum. To mimic human methanol\udmetabolism, folate deficient animals were used.\udMethod: Animal weight, complete hemogram, marker enzyme in serum, some selected serum\udprofile reflect liver and kidney function, plasma corticosterone level, and in serum, lipid\udperoxidation, nitric oxide, enzymatic and non-enzymatic antioxidant level was measured .\udResult: After 15 d of aspartame administration animals showed a significant change in marker\udenzymes, and antioxidant level. However, after repeated long term administration (30 d and 90 d)\udshowed a significant change in some selected serum profile reflects liver and kidney function,\udalong with marker enzymes, and antioxidant level.\udConclusions: This study concludes that oral administration of aspartame (40 mg/kg body weight)\udcauses oxidative stress in Wistar albino rats by altering their oxidant/antioxidant balance