Open AccessAntihyperglycemic activity of Areca Catechu flowers
Author(s) -
Rupesh Ghate,
Shivakumar Hugar,
Nanjappaiah Hanakunte Matha,
Navanath V. Kalyane
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60430-8
Subject(s) - catechu , alloxan , areca , phytochemical , traditional medicine , chemistry , petroleum ether , diabetes mellitus , ethanol , body weight , aqueous solution , pharmacology , medicine , biochemistry , chromatography , endocrinology , extraction (chemistry) , structural engineering , nut , engineering
Objective: To evaluate the antidiabetic effect of Areca catechu (A. catechu) flower extracts in\udalloxan induced diabetic rats.\udMethods: Petroleum ether, ethanol and aqueous extracts of A. catechu flowers were administrated\udorally at the dose of 500 mg/kg for hypoglycemic effect in alloxan induced diabetic rats for 21\udd. The anti-diabetic potential was validated through various biochemical parameters and body\udweight.\udResults: The results revealed that, the ethanol and aqueous extracts of A. catechu flowers\udhave shown a significant antidiabetic efficacy in alloxan induced diabetic rats. Further, this is\udconfirmed by significantly restoring the levels of biochemical parameters and improvement in\udbody weight. Preliminary phytochemical investigation reveals high phenolic constituents in both\udextracts.\udConclusions: The significant antihyperglycemic effect of ethanol and aqueous extracts in alloxan\udinduced diabetic rats could be due to high phenolic constituents by effectively reversing the\udlevels of biochemical parameters and also improvement in body weight. So it might be of value in\udthe treatment of diabetes