Open AccessEvaluation of hepatoprotective activity of alcoholic and aqueous extracts of Selaginella lepidophylla
Author(s) -
Prashant Tiwari,
Dheeraj Ahirwae,
Anish Chandy,
Bharti Ahirwar
Publication year - 2014
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(14)60419-9
Subject(s) - aqueous extract , ccl4 , traditional medicine , chemistry , liver injury , carbon tetrachloride , aqueous solution , pharmacology , medicine , organic chemistry
Objective: To screen Selaginella lepidophylla (S. lepidophylla) that are used in traditional\udmedicine for their claimed hepatoprotective properties.\udMethods: Alcoholic and aqueous extracts of S. lepidophylla were evaluated for their\udhepatoprotective activity using CCl4 and paracetamol induced acute hepatic injury model.\udResults: Treatment with CCl\ud4 and paracetamol significantly increased liver weight and volume\udcompared to the normal group. Pretreatment with silymarin alcoholic and aqueous extracts\udsignificantly prevent increase in liver weight and volume.\udConclusions: From the present experimental study it can be concluded that alcoholic and\udaqueous extract of S. lepidophylla exhibited significant hepatoprotective activity against CCl4\udand paracetamol induced hepatotoxicity in rats, as result showed in physical, biochemical and\udhistopathological parameters