Open AccessIn-vivo anti-inflammatory and anti-pyretic activities of Manilkara zapota leaves in albino Wistar rats
Author(s) -
Amlan Ganguly,
Zobaer Al Mahmud,
Munira Nasiruddin,
SM Abdur Rahman
Publication year - 2013
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(13)60073-0
Subject(s) - petroleum ether , chemistry , traditional medicine , carrageenan , in vivo , ethyl acetate , anti inflammatory , ethanol , pharmacology , biochemistry , chromatography , medicine , biology , extraction (chemistry) , microbiology and biotechnology
Objective: To screen ethanolic extracts of Manilkara zapota leaves (Family: Sapotaceae) and\udits different solvent soluble fractions for possible anti-inflammatory, anti-pyretic activities in\udexperimental albino Wistar rats.\udMethods: Anti-inflammatory activity was evaluated by carrageenan induced paw edema method;\udanti-pyretic potential was determined by yeast-induced pyrexia method in albino Wistar rats.\udResults: In evaluation of anti-inflammatory activity the crude ethanolic (300 mg/kg) and ethyl\udacetate extract (300 mg/kg) showed significant inhibition of paw edema by 91.98% and 92.41%\ud(P<0.001) respectively at 4th h compared to standard diclofenac (86.08% inhibition). In anti-pyretic\udstudy by yeast-induced pyrexia in albino Wistar rats, the ethanol extract (300 mg/kg) reduced\udtemperature from 37.90 °C to 37.41 °C (P<0.01) and 37.07 °C (P<0.001) in 3rd and 4th h respectively.\udSimilarly, both petroleum ether and ethyl acetate fractions exhibited significant anti-pyretic\udproperty (P<0.001). The maximum body temperature lowering effect (36.86 °C) was noticed by\udpetroleum ether fraction.\udConclusions: The findings of the studies demonstrated both anti-inflammatory and antipyretic activities of the leaves of Manilkara zapota which could be the therapeutic option against\udinflammatory disease and pyrexia