Open AccessHomology modeling and validation of SAS2271 transcriptional regulator of AraC family in Staphylococcus aureus
Author(s) -
Money Gupta,
Gulshan Wadhwa,
Sanjeev Sharma,
Chakresh Kumar Jain
Publication year - 2013
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(13)60001-8
Subject(s) - virulence , staphylococcus aureus , regulator , homology modeling , homology (biology) , ramachandran plot , genetics , biology , virulence factor , transcription factor , computational biology , gene , microbiology and biotechnology , protein structure , bacteria , biochemistry , enzyme
Objective: To predict three dimensional structure of AraC Family transcription regulator protein\udin staphylococcus aureus involved in causing virulence. Methods: Evolutionary dynamics of S.\udaureus reveled that several mutations preceding virulence lead to truncated proteins that plays\udan important role in virulence. The Structural templates are identified using homology search\udand then homology modelling is used to get the 3-D structure of the protein. Results: The 3-D\udstructure of SAS2271 transcriptional factor of AraC family in MSSA476 strain of S. aureus was\udmodelled and validated using the Ramachandran plot. Conclusions: The knowledge of 3-D\udstructure of the protein will be helpful in identifying its biochemical function along with its\udregulatory mechanism in causing virulence