Open AccessSynergistic effect of Commiphora mukul (gum resin) and Lagenaria siceraria (fruit) extracts in high fat diet induced obese rats
Author(s) -
Sayyed Nadeem
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60285-0
Subject(s) - lagenaria , traditional medicine , chemistry , triglyceride , cholesterol , medicine , botany , biochemistry , biology
Objective: To investigate the synergistic effect of Commiphora mukul (gum resin) and Lagenaria\udsiceraria (fruit) extracts in high fat diet induced obese rats. Methods: Rats were randomly\uddivided into seven groups: (i) non-obese control (NOB), (ii) Obese control (OB), (iii) orlistat (50 mg/\udkg; p.o. ), (iv) ethyl acetate extract of Commiphora mukul (gum resin) (200 mg/kg; p.o. ), (v) ethanolic\udextract of Lagenaria siceraria (fruit) (200 mg/kg; p.o. ) were examined individually, (vi) C. mukul\udand L.siceraria (200 mg/kg; p.o. ) and (vii) C. mukul and L.siceraria (400 mg/kg; p.o. )extracts were\udadministered in combination to the high fat-diet-induced obese rats for 30 days to evaluate its\udsynergistic activity. Results: For synergistic effect, after combination treatment caused most\udsignificant (P<0.001) reduction in body weight, fasting blood glucose, serum levels of cholesterol,\udtriglyceride, LDL, VLDL and increase levels of HDL. Conclusions: The result demonstrated that\udcombination C.mukul and L.siceraria has ameliorated the high fat diet induced obesity