Open AccessMoringa oleifera Lam. A herbal medicine for hyperlipidemia: A pre–clinical report
Author(s) -
R Ganesan,
MN Satishkumar,
K. P. Elango,
B. Suresh
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60266-7
Subject(s) - moringa , hyperlipidemia , medicine , traditional medicine , proinflammatory cytokine , antioxidant , pharmacology , low density lipoprotein , high density lipoprotein , cholesterol , chemistry , biochemistry , endocrinology , inflammation , diabetes mellitus
Objective: Herbal medicine is a use of plant’s seeds, roots, barks, leaves, berries or flowers for\udmedicinal purposes. In this present study, leaves of Moringa oleifera Lam were evaluated for its\udhypolipidemic, antioxidant, anticoagulant, platelet antiaggregatory and antiinflammatory activity\udin experimental animals. Methods: The experimental animals were divided into five groups of\udmale Wistar rats each. The hydroalcoholic extract of Moringa oleifera (HEMO) was prepared and\udadministered orally to hyperlipidemic rats for a period of 28 days. Results: The results showed\udthat oral administration of HEMO at two different dose level (100 and 200mg/kg/b.wt) showed\udsignificant (P<0.001) reduction in elevated levels of body weight, total cholesterol, triglycerides,\udlow density lipoprotein, very low density lipoprotein and similarly significant (P<0.001) increase\udin high density lipoprotein level. Atherogenic index was significantly reduced in the Moringa\udoleifera treated groups at tested dose levels. The antioxidant parameters of SOD, Catalase, MDA\udwas significant (P<0.001) in vivo. The intravenous administration of HEMO delayed the plasma\udrecalcification time in rabbits and also inhibited ADP induced platelet aggregation in vitro, which\udwas comparable to commercial heparin. The significant (P<0.001) inhibition of proinflammatory\udcytokines like TNF-毩 and IL-1毩 by HEMO were taken as it s antiinflammatory activity.\udConclusions: All these results revealed the therapeutic potential of HEMO against vascular\udintimal damage and atherogenesis leading to various types of cardiovascular complications. Thus,\udMoringa oleifera can be prescribed as food appendage for coronary artery disease patients along\udwith their regular medicines