Open AccessHepatoprotective activity of methanolic extract of Barleria montana leaves in ethanol treated rats
Author(s) -
Shanaz Banu,
G. Arunachalam,
K. N. Jayaveera,
VL Ashoka Babu,
Vijay Kumar
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60257-6
Subject(s) - catalase , superoxide dismutase , antioxidant , chemistry , traditional medicine , ethanol , in vivo , liver function , bilirubin , enzyme , pharmacology , biochemistry , medicine , biology , microbiology and biotechnology
Objective: The present study was undertaken to investigate the protective effect and possible\udmechanism of methanolic extract of Barleria montana (BM) on ethanol-induced rat hepatic injury.\udMethod: This respective activity was assessed through monitoring liver function tests through the\udmeasurement of triglycerides, cholesterol, total protein, total bilirubin, serum enzymes like SGOT\udand SGPT and in vivo antioxidant parameters like lipid peroxidase, Superoxide dismutase(SOD)\udand catalase,. Further, hepatic tissues were also subjected to histopathological studies. Result:\udPretreatment of BM methanolic extract (500mg/kg) reduced the fatty liver symptoms and significantly\ud(p<0.001) inhibited the increase of respective serum enzyme levels. Conclusions: The results of the\udpresent study indicated that BM methanolic extract possess hepatoprotective effects which could act\udas an effective treatment for acute hepatic diseases