Studies on the antidandruff activity of the essential oil of coleus amboinicus and eucalyptus globulus

Objective: To determine the effect of the essential oil of Coleus amboinicus and Eucalyptus\udglobules as potential antidandruff agent. Methods: Fresh leaves of Coleus amboinicus and\udEucalyptus globules were collected from the Horticultural Research Station, Yercaud, Salem,\udTamil Nadu, India. The collected leaves were washed thoroughly and shade dried for 7-10\uddays. The essential oils from both the dried plant leaves were obtained by hydro distillation\udprocedure. The chemical compositions of hydro distilled essential oils were analyzed by Gas\udChromatography-Mass spectrometry (GC-MS). The pure essential oils and the essential oils\uddiluted with coconut oil of the two plants were used to check antidandruff activity against the\uddandruff causing fungus Malassezia furfur by agar well diffusion assay. Results: The average\udyield of essential oil from Coleus amboinicus (0.89%) and Eucalyptus globules (0.77%). The results\udof GC-MS revealed that the presence of eight compounds from Coleus amboinicus essential oil\udand five constituents from Eucalyptus globules representing 90.45% and 96.32% of the total oil\udrespectively. The major component was identified as Thymol (phenolic rich compocnd) (41.3%)\udin Coleus amboinicus and in Eucalyptus globules the major constituents was 1-8, Cineol (91.61%).\udIn the antidandruff activity the broad range of inhibitory zone was observed in Eucalyptus\udglobules (37mm) oil compare to Coleus amboinicus (31mm). Ketaconazole based shampoo used as a\udstandard. Conclusion: This study would direct to the establishment of a natural compound from\udColeus amboinicus and Eucalyptus globules as an antidandruff agent which can be used for the\udproduction of potential antifungal drug and novel pharmaceutical and cosmeceutical leads