Open AccessToxicological evaluation of ethanolic extract of Tabernaemontana coronaria (L) R. Br.
Author(s) -
Poornima Kannappan,
Remya Krishnan,
K Aswathi,
Vishrawas Gopalakrishnan
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60243-6
Subject(s) - acute toxicity , traditional medicine , kidney , pharmacology , toxicity , lipid profile , medicine , cholesterol
Objective: To investigate the acute and sub acute toxicological evaluation of ethanolic extract of\udTabernaemontana coronaria. Method: The acute toxicity profile as well as possible haemostatic\udactivity of the ethanolic extract of the plant after sub acute oral administration was studied in\udmale wistar albino rats.The rats were sacrificed 24 h after last treatment. Blood was collected by\udcervical decapitation for biochemical and haematological assessment. Liver and kidney were\udalso excised, placed in 10% formalin for histopathological evaluation. Results: The ethanolic\udextract of Tabernaemontana coronaria did not produce any significant effect on haematology,\udlipid profile and renal profile. But only a slight increase in ALP and LDH is seen in group V rats.\udThe histopathological study did not show any abnormalities in the liver and kidney. Conclusion:\udAlthough the ethanolic extract of Tabernaemontana coronaria has shown only slight increase in\udALP and LDH activity in group 5 rats, the histopathological study confirmed the safety nature of\udthe plant