Open AccessIn vivo anti–nociceptive and anti–inflammatory activities of Lippia alba
Author(s) -
Sourav Haldar,
Biswakanth Kar,
Narayan Dolai,
Rajesh Kumar,
Biswaranjan Behera,
Pallab Kanti Haldar
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60241-2
Subject(s) - petroleum ether , lippia , nociception , traditional medicine , carrageenan , in vivo , verbenaceae , chloroform , chemistry , rosa × damascena , pharmacology , anti inflammatory , extraction (chemistry) , essential oil , medicine , chromatography , biology , biochemistry , microbiology and biotechnology , receptor
Objective: To evaluate antinociceptive and anti-inflammatory activities of Lippia alba (Mill.) N.E.\udBrown (Verbenaceae) leaves. Methods: Soxhlet extraction method was used to obtain extracts\udusing petroleum ether extracts (PELA); chloroform extracts (CELA); ethanol extracts (EELA) and\udaqueous extract (AELA). Antinociceptive activity was assessed on rats by tail flick latency using\udtail immersion method and anti-inflammatory activity was estimated by carrageenan induced\udpaw edema method. PELA, CELA and AELA at a dose of 500 mg /kg.b.wt. and EELA at a dose of\ud460 mg /kg.b.wt were administered orally. Result: Competing to control AELA was found to have\uda higher range of anti-nociceptive activity and showing maximum (79.66%) response at 60 min,\udwhere as CELA and EELA were found to have a maximum range of anti-inflammatory activity\udand CELA exhibit maximum (19.5%) response at 240 min. Conclusion: The results suggest that the\udextracts of Lippia alba possess ant-inociceptive and anti-inflammatory activities, and its help to\udauthenticates the use of the plant in the traditional treatment of ailments associated with pain and\udinflammation