Open AccessAntioxidant and wound healing potential of Pistia stratiotes L.
Author(s) -
Mithilesh Kumar Jha,
Versha Sharma,
N. Ganesh
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60225-4
Subject(s) - pistia , wound healing , antioxidant , ascorbic acid , stratiotes , pharmacology , traditional medicine , medicine , vaseline , chemistry , surgery , food science , biochemistry , biology , ecology , aquatic plant , macrophyte
Objective: To investigate the effects of Pistia stratiotes on wound healing activity in Swiss albino\udmice by excision wound healing model and its antioxidant study was performed to understand\udthe mechanism of wound healing potency.Methods: Mice were topically treated with extract\udformulated in ointment by using simple ointment vaseline as base. 5% and 10% (w/w) ointment\udwas applied once daily. A standard group was treated with Povidone iodine ointment topically.\udThe area of wound was measured on 4, 6, 8, 10, 12, 14, 16 post-wounding days. The scar area\udon complete epithelization was measured. The parameters observed were wound contraction\ud(mm2), epithelization period and tensile strength including histopathological studies. Antioxidant\udactivity was determined by in vitro method-H2O2 radical scavenging. Results: Treatment of\udwound with ointment containing 5% and 10% (w/w) extract of Pistia stratiotes exhibited significant\ud(P < 0.001) wound healing activity when compared with control group. All parameters such as\udwound contraction (mm2), epithelization period and tensile strength and histopathological studies\udshowed significant changes when compared to control. Extracts possess significant antioxidant\udactivity compared to control group. Ascorbic acid was used as reference standard for antioxidant\udactivity (P<0.001 vs Ascorbic acid). Conclusion: The results conclude that Pistia stratiotes has\udantioxidant properties, which may be responsible and favorable for faster wound healing and this\udplant extract may be useful in the management of wounds, it also supports its traditional use