Open AccessA current status of adaptogens: natural remedy to stress
Author(s) -
Vinod S Pawar,
Shivakumar Hugar
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60207-2
Subject(s) - chronic stress , medicine , anxiety , depression (economics) , disease , physiology , intensive care medicine , bioinformatics , endocrinology , psychiatry , biology , economics , macroeconomics
Stress is a normal part of everyday life but it is important to be able to use tools for its\udmanagement otherwise chronic stress, if left untreated, can lead to a variety of stress related\udillnesses including hypertension, heart disease, anxiety, depression, memory impairment and\udchronic fatigue syndrome. The aim of this literature review is to summarize and critically analyze\udresearch conducted on the adaptogenic herbs. The aim of this review article is to assess the level\udof scientific evidence presented by the adaptogens from natural origin by different screening\udmethods and to provide a rationale at the molecular level. Strong scientific evidence is available\udin relation with the molecular mechanisms associated with their stress- protective activity\udagainst acute and chronic paradigms. The beneficial stress- protective effect of adaptogens is\udin relation with regulation of homeostasis via several mechanisms of action associated with the\udhypothalamic- pituitary-adrenal axis and the control of key stress mediators and biochemical\udmarkers such as nitric oxide (NO), cortisol, cholesterol, triglycerides, glucose etc. Good scientific\udevidence has been documented with active secondary metabolites present in adaptogens