Open AccessEffects of Lactuca sativa extract on exploratory behavior pattern, locomotor activity and anxiety in mice
Author(s) -
S N Harsha,
K.R. Anilakumar
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60206-0
Subject(s) - lactuca , anxiolytic , elevated plus maze , open field , diazepam , leafy vegetables , body weight , locomotor activity , chemistry , traditional medicine , pharmacology , biology , anxiety , botany , food science , medicine , endocrinology , psychiatry
Objective: To evaluate antianxiety property of Lactuca sativa, an important and commonly used\udleafy vegetable known for its medicinal properties belongs to Asteraceae family. Methods:\udElevated plus maze (EPM), open field test (OFT), rat exposure test, hyponeophagia and marble\udburying test were performed in mice models to assess the exploratory behaviour and to assess\udanxiolytic property of hydro-alcohol extract of Lactuca sativa. Diazepam (1 mg/kg body wt.)\udserved as the standard anxiolytic agent for all the tests. The dried extract of the plant leaf in\uddoses of 100, 200 and 400 mg/kg body weight was administered orally to mice for duration of 15 or\ud30 days and evaluated exploratory behaviour, locomotor and anxiolytic activities. Results: Time\udspent and number of entries into the open arm was measured in EPM followed by total locomotor\udactivity in OFT and latency to enter the food zone in hyponeophagia. Conclusions: The study\udsuggested that hydro-alcohol extract of Lactuca sativa leaves possess potent anxiolytic property