Open AccessEvaluation of Polyherbal formulation for Diuretic activity in albino rats
Author(s) -
Sahoo Himanshu Bhusan,
Asati Anuj Kumar,
Toppo Fedelic Ashish,
Kori Mohan Lal
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60200-x
Subject(s) - diuretic , furosemide , urine , chemistry , excretion , pharmacology , osmotic concentration , urine osmolality , traditional medicine , medicine , biochemistry , organic chemistry
Objective: To investigate the diuretic potential of Polyherbal formulations prepared from\udthe seeds of Vitis venifera, Duranta repens and Centratherum anthelminticum in Albino rats.\udMethods: Different concentrations of Polyherbal formulations (100, 200 and 400 mg/kg), furosemide\ud(10 mg/kg) and vehicle were orally administered to rat (n = 6 animals per group) and their urine\udoutput was collected after 24h. The Urinary output, Osmolarity, pH, Na+, K+ and Cl- concentrations\udof urine were estimated. Results: The Polyherbal formulations produced significant increase\udin Na+, K+, Cl- excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic\udindex and Natruretic index. All the concentrations of Polyherbal formulation showed dosedependent relationship when compared to control animals. Conclusions: These finding strongly\udsuggests that the Polyherbal formulations have a good diuretic activity on rats in the above\udexperimental model