In-vitro anthelmintic activity of Coleus aromaticus root in Indian Adult Earthworm

Objective: Anthelmintic resistance creates a major hitch over the decades throughout the world.\udAs per WHO only synthetic drugs are frequently used in the treatment of helminth infestations in\udhuman beings but these synthetic drugs are out of reach of millions of people and have a lot of\udside effects. In view of this, an attempt has been made to study the anthelmintic activity of herbal\uddrug. Methods: All the prototypes and the standard drug solution were freshly prepared before\udcommencement of the experiments. All the earthworms were washed in normal saline solution\udbefore they were released into 10 ml of respective formulation as follows, vehicle (2% v/v Tween 80\udin normal saline), and Piperazine Citrate (10 mg/ml) and prototypes (10, 20 and 50mg/ml). Results:\udAll the investigational extract acquired the anthelmintic activity at minimal dose of 10 mg/ml. its\udsignificant activity (P<0.05) at 10 mg/ml for time taken to paralysis and death when compared to\udthe standard drugs Piperzine citrate used at 10 mg/ml respectively. Conclusions: Herbal\uddrugs and synthetic drugs have equally effective in helminth infestations but methanolic extract\udhas the maximum anthelmintic activity potential than other root extract of Coleus aromaticus