Open AccessIsolation and characterization of Marine fungal metabolites against clinical pathogens
Author(s) -
Rajasekar Thirunavukkarasu,
Sudharsan Balaji,
Kumaran Shanmugam,
B. Deivasigamani,
S.R. Pugzhavendhan
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60187-x
Subject(s) - fungus , penicillium , antimicrobial , biology , microbiology and biotechnology , isolation (microbiology) , fusarium , mangrove , aspergillus , marine fungi , aspergillus fumigatus , agar , agar plate , mucor , acremonium , bacteria , food science , botany , ecology , genetics
Objective: To isolate and identify of marine fungal metabolites against clinical bacterial\udpathogens. To optimize the production medium for isolated fungus. Method: Marine fungus\udisolated from water and sediment samples from different places of Sundarbans mangrove,\udMuttukadu (Chennai) and Parangipettai in India. Antimicrobial substance from marine fungi\udwas produced by agar plate method. The potent fungal were inoculated on production medium\udand extracted was done. The extracted compound was checked for anti bacterial activity.\udSuitable production medium were optimized. Result: Totally 30 fungal isolates were recovered\udand morphologically 10 different strains were belongs to the fungal genera such as Fusarium,\udAspergillus, Mucor and Penicillium. Preliminary screening results showed 3 fungal isolates\udshowed promising activity. After production of potent fungal SS2 crude extracts showed highest\udinhibition against the bacterial pathogens out of 3 fungal isolates. The results showed maximum\udzone in 20mm against E.coli and minimum 10 mm against Vibrio sp. Conclusions: The present\udstudy identified Fusarium sp isolated from Sundarbans mangrove water as a potential source for\udbioactive compounds. Further isolation of active compound from potential fungal isolates will\udleads to the discovery of effective antimicrobials