Open AccessPharmacognostic study and anti – inflammatory activity of Phyllanthus reticulatus Poir. fruit
Author(s) -
Sunil Kumar,
Shalini Sharma,
Dinesh Kumar,
Tarun Kumar,
Renu Arya,
Karunesh Kumar
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60177-7
Subject(s) - diclofenac sodium , traditional medicine , phyllanthus , anti inflammatory , diclofenac , carrageenan , chemistry , botany , pharmacology , biology , food science , medicine , biochemistry
Objective: To study pharmacognostic evaluation and anti - inflammatory activity of Phyllanthus\udreticulatus Poir. (P.reticulatus) fruit. Methods: The fruit sample was studied by macroscopical,\udmicroscopical and other WHO recommended methods for standardisation. The hydroalcoholic\udextract of ripe fruit was also screened for anti-inflammatory activity by carrageenan induced\udleft hind paw oedema in rat at doses of 200 mg/kg and 400 mg/kg, orally. Results: Transverse\udsection of fruit and powder study showed the presence of epicarp, mesocarp, endocarp, fibres\udand sclereids. Hydroalcoholic extract of fruit showed significant (P<0.01 ) reduction of paw\udvolume when compared with diclofenac sodium. The extract showed anti - inflammatory\udactivity at 200 mg/kg and 400 mg/kg and was comparable with diclofenac sodium. Conclusions:\udPharmacognostic profile of Phyllanthus reticulatus provides the simplest and quickest means to\udestablish the identity and purity and thereby assure the quality of sample. The hydroalcoholic\udextract shows significant anti - inflammatory activity at both doses when compared with standard\uddrug diclofenac sodium (100 mg/kg)