Open AccessImpact of G. applanatum, a multifunctional herbal extract on haematological profiles of laboratory rats: a preliminary study in Nigeria
Author(s) -
Akpera mt,
BO Oguntayo,
Gta Jombo
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60165-0
Subject(s) - white blood cell , trypanosoma brucei , trypanosomiasis , aqueous extract , red blood cell , biology , blood cell , pharmacology , traditional medicine , physiology , veterinary medicine , medicine , immunology , andrology , biochemistry , gene
Objective: To ascertain the haematological properties of aqueous extract of G. applanatum(G.\udapplanatum). Methods: Sixty albino rats were grouped into six equal groups (10 each) from A\udto F, consisting of tests and controls. Laboratory albino rats in groups A, B and C were infected\udwith Trypanosoma brucei (T. brucei) while groups A and B (Test) were treated with aqueous G.\udapplanatum extract; other groups served as control. Microscopy and haematological profiles from\udthe albino rats were monitored on daily basis for blood parasites, Packed Cell Volume (PCV),\udHaemoglobin Concentration (HC), Total Red Blood Cell Count (RBC), Mean Cell Haemoglobin\ud(MCH), Mean Cell Volume (MCV), Mean Cell Haemoglobin Concentration (MCHC), and Total White\udBlood Cell Count (WBC). Results: Albino rats in groups A, B and C infected with T. brucei and\udtreated with various concentrations of aqueous G. applanatum showed a progressive reduction\udin PCV, HC, RBC, MCH and MCHC compared to the controls (P< 0.05). All the infected rats died\udby day 14 of the experiment from parasitaemia. Conclusions: G. applanatum lacks ability to\udboost haematological profiles of anaemic laboratory rats and also of no use in the treatment of\udAfrican Trypanosomiasis. Higher doses of the fungal extract may be required to test on laboratory\udrats with less lethal biological stimulants of anaemia before proving or otherwise its true\udhaematological properties