Open AccessHepatoprotective activity of Mentha arvensis Linn. leaves against CCL4 induced liver damage in rats
Author(s) -
Kamal Patil,
Alka Mall
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60156-x
Subject(s) - mentha arvensis , ccl4 , chemistry , phytochemical , traditional medicine , bilirubin , carbon tetrachloride , chloroform , ethanol , pharmacology , transaminase , biochemistry , enzyme , biology , food science , medicine , chromatography , essential oil , organic chemistry , endocrinology
Objective: To study the Hepatoprotective activity of ethanol, chloroform and aqueous extracts of\udMentha arvensis leaves against CCL4 induced liver damage in rats. Methods: Hepatotoxicity was\udinduced by CCL4 and the biochemical parameters such as serum glutamate pyruvate transminase\ud(sGPT), serum glutamate oxaloacetate transaminase (sGOT), alkaline phosphatase (sALP), serum\udbilirubin (sB) and histopathological changes in liver were studied along with silymarin as\udstandard Hepatoprotective agents. Results: The Phytochemical investigation of the extracts\udshowed presence of flavonoids, steroids, triterpenoids, alkaloids, glycosides, carbohydrates,\udtannins, phenolic compounds. Treatment of the rats with chloroform, ethanol and aqueous extract\udwith CCL\ud4 administration caused a significant reduction in the values of sGOT, sGPT, sALP\udand sB (P<0.01) almost comparable to the silymarin. The Hepatoprotective was confirmed by\udhistopathological examination of the liver tissue of control and treated animals. Conclusions:\udFrom the results it can be concluded that Mentha arvensis possesses Hepatoprotective effect\udagainst CCL4 induced liver damage in rats