Open AccessSystematic Evaluation of Antiulcer Activity of Herbal Formulation ‘Chandanasava’ in Rats
Author(s) -
Pankaj Dixit,
Praveen Kumar Sharma,
Dinesh Kumar Jain,
Vikas Jharia
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60150-9
Subject(s) - aspirin , mucus , pylorus , medicine , ethanol , antiulcer drug , pharmacology , gastroenterology , stomach , chemistry , drug , biochemistry , ecology , biology
Objective: To evaluate three formulations of ‘Chandanasava’ [commercially made by\udBaidyanath, Dabur and test (prepared in-house)] for anti-ulcer activity. Methods: The activity\udwas evaluated in Albino wistar rats against ethanol induced, aspirin induced, cold restraint\udinduced and pylorus ligation induced gastric ulcer models. The formulations were administered\udorally at the dose of 6 ml/kg. Results: The percentage inhibition of ulcer formation in the ethanol\udinduced ulcer model 66.51%, 74.76% and 78.85% respectively, in the aspirin induced ulcer model\ud78.30%, 72.30% and 68.69% respectively; in cold restraint stress ulcer model 78.57%, 76.28% and\ud73.85% respectively for Baidyanath, Dabur and test formulations. Further, the pylorus ligated rats\udtreated with Chandanasava exhibited significantly (P < 0.001) decreased ulcer lesions, gastric\udvolume, and total acidity. It was found to prevent the ulceration by increasing the pH and mucus\udsecretion in pylorus ligated rats.Conclusions: The formulations of ‘Chandanasava’ possess\udsignificant antiulcer activity in variety of preclinical models and should be further evaluated to\udsubstantiate the findings