Anti-obesity and hypoglycemic effect of ethanolic extract of Murraya koenigii (L) leaves in high fatty diet rats

Objective: To evaluate the hypoglycemic and anti-obesity activities of of Murraya koenigii\udleaves. Method: The study was performed in high fatty diet induced obesity rats. After 15 days\udbaseline period the treatments animals were received ethanolic extract of Murraya koenigii\udleaves (300 and 500 mg/kg) in high fatty diet rats. All the treatments were given for one month. On\ud30th day all the fasted animals received an intraperitoneal injection of glucose (1 g/kg) for glucose\udtolerance test. At the end of study body weight, total cholesterol, triglycerides, and blood glucose\udlevel were measured. Results: The results demonstrate clearly that repeated oral administration\udof Murraya koenigii leaves evoked a potent anti-hyperglycaemic activity in high fat diet obese\udrats. Postprandial hyperglycaemic peaks were significantly lower in plant-treated experimental\udgroups. In other hand, high fatty diet group increased the both total cholesterol and triglycerides\udlevels as compared to control group. While administration of Murraya koenigii leaves significantly\uddecreased in both cholesterol as well as triglycerides. Conclusions: We can conclude that\udMurraya koenigii leaves evokes potent anti-hyperglycaemic and anti-obesity effects. This fact\udcould support their use by the diabetes patient for controlling body weight as well as maintains\udthe glycemic level