Open AccessAntifertility effect of chronically administered Tabernaemontana divaricata leaf extract on female albino mice
Author(s) -
Sachin Jain,
Dinesh Kumar Jain,
Neelam Balekar,
Ankit Jain
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60143-1
Subject(s) - estrous cycle , luteinizing hormone , ovulation , body weight , follicle stimulating hormone , hormone , endocrinology , medicine , biology
Objective: To study the antifertility activity of Tabernaemontana divaricata leaf extract on\udfemale albino mice. Methods: Animals were divided into three groups consisting of five animals\udin each group. One group served as control and received vehicle orally for 21 days. The other two\udgroups received dried ethanolic extract of leaves orally at a dose of 250 and 450 mg/kg animal\udbody weight per day. After 21 days of treatment, extract was withdrawn from the mice and estrous\udcycle was studied for another 21 days. Results: The results of this study revealed that treatment\udof mice with extract of 250 and 450 mg/kg body weight for 21 days caused a prolonged eastrous\udcycle with significant increase in the duration of diestrus phase and elongation of estrus stage\udin treatment with higher dose (450 mg/kg body weight) and simultaneously decrease in the\udluteinizing hormone (LH) in both the treated groups and follicle stimulating hormone (FSH) in\udhigher dose of treatment compared to the control animals may indicate the disturbance of estrous\udcycle and ovulation through suppression of FSH. Conclusions: It concludes that disturbance on\udthe estradiol secretion with significant decrease during estrous stage of the cycle observed with\udthe extract treatment may be due to impairment of LH and FSH