Open AccessCorrelation of Serum Endothelial Dysfunction Markers with CT Angiographic Findings in Ischemic Stroke
Author(s) -
Neeraj Varyani,
Suchi Tripathi,
Anubhav Thukral,
Manish Mishra,
Sunny Garg,
Kamlakar Tripathi,
Amit Nandan Dhar Dwivedi
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60115-7
Subject(s) - medicine , endothelial dysfunction , stroke (engine) , surrogate endpoint , angiography , oxidative stress , cardiology , disease , pathology , mechanical engineering , engineering
Objective: Endothelial dysfunction is considered as root cause of vascular diseases like stroke,\udmyocardial infarction (MI) and venous thromboembolism. Soluble endothelial dysfunction\udmarkers are emerging as surrogate markers of disease risk. We aim to correlate the findings of\udComputed Tomography Angiography (CTA) with biochemical markers of endothelial dysfunction\udin patients of stroke. Material and method: 40 patients diagnosed to have ischemic stroke\udor Transient Ischemic Attack (TIA) based on clinical history, examinations and imaging were\udincluded. We assessed high sensitive C - reactive protein (hsCRP), total nitric oxide (NO) and\udsuperoxide dismutase (SOD) levels in all patients within 24 hours and CT-Angiography of bilateral\udneck vessels within 48 hours of hospital admission. Results: Increase in hsCRP, NO and decrease\udin SOD was significant in cases as compared to controls. These biochemical markers correlated\udsignificantly with CT Angiographic findings. Conclusions: This study demonstrates that hsCRP,\udNO and SOD is good surrogate biochemical markers for assessing disease risk and burden in\udischemic stroke. These surrogate markers showed a linear correlation and statistical significance\udwith CT angiography score. Specific intervention targeted to reduce the oxidative stress, as\udindicated by these markers, and imaging findings should be a part of stroke management\udprotocol