Open AccessAntihypertensive effect of rhizome part of Acorus calamus on renal artery occlusion induced hypertension in rats
Author(s) -
Pinal Patel,
Jitendra Vaghasiya,
Ashokji Thakor,
Jitesh Jariwala
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60114-5
Subject(s) - acorus calamus , blood pressure , medicine , nitric oxide , endocrinology , lipid peroxidation , plasma renin activity , glutathione peroxidase , chemistry , superoxide dismutase , renin–angiotensin system , oxidative stress , rhizome , traditional medicine
Objective: The rhizomes part of Acorus calamus (AC) having the calcium inhibitory effect and\uddiuretic activity which may potentiate Na+ excretion in hypertension induced by occlusion of\udrenal artery. Therefore this study was aimed to investigate the effect of AC on experimentally\udinduced hypertension. Methods: Hypertension in rats was induced by clamping the left renal\udartery for 4h by arterial clamp (2K1C). At the end of experiment animal were anesthetized with\udketamine (50 mg/kg). Carotid artery was cannulated which was connected to pressure transducer\udfor estimation of blood pressure. Results: Ethyl acetate extract of Acorus calamus rhizomes (EAAC)\udtreated rats that underwent hypertension, demonstrated significant (P < 0.01) lower systolic blood\udpressure and diastolic blood pressure when compared with 2K1C rats indicated blood pressure\udlowering activity. Plasma renin activity was significantly (P < 0.05) decreased in EAAC treated\udrats compared to 2K1C rats. EAAC treated rats that underwent hypertension demonstrated\udsignificant (P < 0.01) lower mean blood urea nitrogen and creatinine when compared with 2K1C\udrats. Lipid peroxidation was significantly (P < 0.001) decreased, where as nitric oxide level in\udtissue was significantly elevated in EAAC treated rats. Antioxidant enzymes like glutathione,\udsuperoxide dismutase and catalase were significantly (P < 0.05, P < 0.01, P < 0.001) increased in\udEAAC treated rats when compared to 2K1C rats. Conclusions: In conclusions, EAAC treatment\udattenuated renal artery occlusion induced hypertension via nitric oxide generation and decreases\udthe plasma renin activity