Open AccessImpact of Ganogerma applanatum extraction on haematological profiles of laboratory rats: a preliminary study in Nigeria
Author(s) -
MT Akpera,
BO Oguntayo,
Gta Jombo
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60085-1
Subject(s) - trypanosoma brucei , african trypanosomiasis , trypanosomiasis , white blood cell , biology , aqueous extract , red blood cell , traditional medicine , blood cell , physiology , veterinary medicine , pharmacology , medicine , immunology , biochemistry , gene
Objective: Extracts of Ganoderma species have been widely used as herbal medicines in the\udtreatment of several infections. This study was carried out to ascertain the haematological\udproperties of aqueous Ganoderma applanatum (G. applanatum). Methods: Sixty albino rats\udgrouped into six equal groups (10 each) of A to F consisting of tests and controls. Laboratory\udalbino rats in groups A, B and C were infected with Trypanosoma brucei brucei (T. brucei brucei)\udwhile groups A and B (test) were treated with aqueous G. applanatum extract; other groups\udserved as control. Microscopy and haematological profiles from the albino rats were monitored\udon daily basis for blood parasites, packed cell volume (PCV), haemoglobin concentration (HC),\udtotal red blood cell count (RBC), mean cell haemoglobin (MCH), mean cell volume (MCV), mean\udcell haemoglobin concentration (MCHC), and total white blood cell count (WBC). Results: Albino\udrats in groups A, B and C infected with T. brucei brucei and treated with various concentrations\udof aqueous G. applanatum showed a progressive reduction in PCV, HC, RBC, MCH and MCHC\udcompared to the controls (P<0.05). All the infected rats died by day 14 of the experiment from\udparasitaemia. Conclusions: G. applanatum lacks ability to boost haematological profiles of\udanaemic laboratory rats and also of no use in the treatment of African trypanosomiasis. Higher\uddoses of the fungal extract may be required to test on laboratory rats with less lethal biological\udstimulants of anaemia before proving or otherwise its true haematological properties