Open AccessA pharmacological evaluation of antidiarrhoeal activity of leaves extract of Murraya koenigii in experimentally induced diarrhoea in rats
Author(s) -
Praveen Kumar Sharma,
G. Vidyasagar,
Anil Bhandari,
Sukhbir Singh,
Upendra Bhadoriya,
Santosh Ghule,
Nitin Dubey
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60052-8
Subject(s) - antidiarrhoeal , murraya , loperamide , traditional medicine , aqueous extract , castor oil , chemistry , medicine , diarrhea , biochemistry
Objective: To evaluate anti-diarrhoeal activity of aqueous and alcoholic extract of the leaves of\udMurraya koenigii (M. koenigii)by using models of castor oil induced diarrhoea, charcoal meal test\udand PGE\ud2 induced diarrhoea. Methods: Alcoholic extract (400 mg/kg) and aqueous extract (200\udmg/kg) of leaves of Murraya koenigii were used with loperamide as standard. Albino Wistar rats\udof both sexes weighing between 150-250 g were used for the anti-diarrhoeal activity. Results:\udThe result suggested that it could act centrally and inhibit the PGE2 to give anti-diarrhoeal\udeffects. Result of charcoal meal test also suggested its anti-muscarnic activity. Conclusions:\udThese findings indicate that aqueous extract of the leaves of M. koenigii displays good antidiarrhoeal activity, corroborating the folk use of M. koenigii preparations and contributing for its\udpharmacological validation