Open AccessHypoglycemic effect of Costus pictus D. Don on alloxan induced type 2 diabetes mellitus in albino rats
Author(s) -
Sevgan Subramanian,
R. Narmadha,
Vishrawas Gopalakrishnan,
Kanakasabapathi Devaki
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60028-0
Subject(s) - lipid peroxidation , alloxan , antioxidant , chemistry , medicine , lipid profile , superoxide dismutase , endocrinology , diabetes mellitus , creatinine , biochemistry , biology
Objective: To demonstrate the effect of aqueous extract of Costus pictus (C. pictus) leaves on\udblood glucose, lipid profile and liver antioxidant enzymes and lipid peroxidation in alloxan\udinduced diabetic rats. Methods: Aqueous extract of C. pictus (AECP) leaves was administered\udorally for 30 days and its effect on blood glucose, lipid profile, hepatic marker enzymes such\udas serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase\ud(SGPT), serum urea, creatinine, protein and albumin content and liver antioxidant enzymes\udsuch as catalase, peroxidase, superoxide dismutase and lipid peroxidation in alloxan induced\uddiabetic rats were examined. Results: Oral administration of aqueous extract of C. pictus leaves\udto diabetic rats for 30 days significantly reduced the levels of blood glucose, lipid profile, lipid\udperoxidation, liver marker enzymes, urea, creatinine and increased the levels of antioxidant\udenzymes. Conclusions: The aqueous extract of C. pictus leaves controls the blood glucose level,\udimproves lipid metabolism and prevents diabetic complications associated with lipid peroxidation\udand also maintains the antioxidant enzymes in experimental diabetic rats. Therefore, it can be\udrecommeded for the prevention of diabetes mellitus