Open AccessNosocomial and community acquired uropathogenic isolates of Proteus mirabilis and antimicrobial susceptibility profiles at a university hospital in Sub–Saharan Africa
Author(s) -
Gta Jombo,
U. E. Emanghe,
EN Amefule,
JG Damen
Publication year - 2012
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(12)60003-6
Subject(s) - proteus mirabilis , nalidixic acid , ciprofloxacin , nitrofurantoin , ampicillin , cloxacillin , microbiology and biotechnology , medicine , cefuroxime , amoxicillin , antibiotic resistance , antibiotics , biology , bacteria , genetics , staphylococcus aureus
Objective: To ascertain antimicrobial susceptibility profile of Proteus mirabilis (P. mirabilis) from\udclinical urine specimens at a university hospital in the spate of its recorded increasing resistance\udpatterns.Methods: The study was retrospective in nature. Data generated from urine cultures\udof patients at University of Calabar Teaching Hospital for a period of five years (2004-2009) were\udcompiled. Relevant information obtained were age and gender of patients, organisms recovered\udand their antibiotic susceptibility patterns. P. mirabilis was identified using standard laboratory\udprocedures. Results: P. mirabilis showed the highest resistance against ampicillin, cloxacillin,\udamoxicillin, tetracycline, co-trimoxazole, erythromycin and chloramphenicol (1 00%-37.2%)\udwhile colistin, ofloxacin, ciprofloxacin, ceftriaxone, nalidixic acid and nitrofurantoin recorded\udthe highest activity (59.1%-96.9%) with no drug recording 100% activity. The resistance of the\udnosocomial isolates of the organism were significantly higher than the community acquired\udisolates against that of the common antibiotics in use (P<0.05). Conclusions: Extreme caution\udshould be exercised in antibiotic administration in hospital setting and the potential benefits\udadequately assessed while control of nosocomial infections be given a priority so as to limit the\udspread of resistant bacteria