Open AccessNon tuberculosis mycobacteria isolates among new and previously treated pulmonary tuberculosis patients in Nigeria
Author(s) -
Olusoji Daniel,
Osman Eltayeb,
Peter Adebiyi,
Mourad Gumusboga,
Etienne Declarcq,
Rasheed Bakare
Publication year - 2011
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(11)60048-0
Subject(s) - mycobacterium chelonae , mycobacterium fortuitum , medicine , tuberculosis , sputum , mycobacterium tuberculosis , mycobacterium , mycobacterium kansasii , sputum culture , nontuberculous mycobacteria , pulmonary tuberculosis , microbiology and biotechnology , pathology , biology
Objective: To determine the prevalence of non tuberculosis mycobacteria (NTM) among new and\udpreviously treated tuberculosis (TB) patients in Nigeria. Methods: It was a retrospective study.\udA total of 102 sputum smear positive samples/culture isolates from pulmonary TB patients (41\udnew smear positive and 61 smear positive retreatment cases) were sent to the Institute of Tropical\udMedicine, Antwerp Belgium between 2007-2009. Data on patients' characteristics were retrieved\udfrom their treatment cards. Results: Among the 102 samples, 25 isolates results (20 were culture\udnegative while 5 were contaminated) were excluded from the study. Data were available for 77\udmycobacterium isolates. 70 (90.9%) were identified as Mycobacterium tuberculosis and 7 (9.1%) as\udatypical mycobacteria. Among the atypical mycobacteria, three of them were Mycobacterium\udfortuitum, two Mycobacterium intracellulare and two Mycobacterium chelonae. Of the seven\udisolates with atypical mycobacteria, 4 (57.1%) were from previously treated patients, while 3 (42.9%)\udwere new sputum positive patients. There was no statistically significant difference in NTM\udinfection between new and previously treated pulmonary TB patients (P=0.97). Conclusions:\udThe study shows the involvement of atypical mycobacterium in pulmonary infection in both\udnew and previously treated TB patients. Therefore, there is a need to carry out culture and drug\udsusceptibility testing in all pulmonary TB patients especially those who had failed conventional\udDOTS treatment to rule out NTM infections