Open AccessIntense and exhaustive exercise induce oxidative stress in skeletal muscle
Author(s) -
T. Thirumalai,
S. V. Therasa,
Elumalai Ek,
David Ernest
Publication year - 2011
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(11)60016-9
Subject(s) - tbars , oxidative stress , superoxide dismutase , glutathione peroxidase , catalase , skeletal muscle , glutathione , antioxidant , thiobarbituric acid , chemistry , endocrinology , medicine , reactive oxygen species , biochemistry , lipid peroxidation , biology , enzyme
Objective: To assess the oxidative stress and antioxidant defense system in the skeletal muscle\udof male albino rats subjected to strenuous exercise programme. Methods: Wistar strain albino\udrats were subjected to exhaustive swimming exercise programme daily for a period of five\uddays. The thiobarbituric acid reactive substances (TBARS), conjugated dienes, superoxide\uddismutase, catalase, glutathione peroxidase and glutathione-S-transferase were measured in\udthe gastrocnemius muscle of the exercised animals. Results: The elevated levels of TBARS and\udconjugated dienes indicated the oxidative stress in the gastrocemius muscle of the exercised\udanimals. The depleted activity levels of superoxide dismutase, catalase, glutathione peroxidase\udand glutathione-S-transferase in the exercise animals indicated the increased oxidative stress\udand decreased antioxidative defense system in the muscle. Conclusions: The study suggests that\udprolonged strenuous exercise programme can induce oxidative stress and therefore an optimal\udlevel of exercise schedule should be advocated to obtain the maximum benefit of exercise\udprogramme