Open AccessAssessment of lipid profile in patients with human immunodeficiency virus (HIV/AIDS) without antiretroviral therapy
Author(s) -
Arun Kumar,
Brijesh Sathian
Publication year - 2011
Publication title -
asian pacific journal of tropical disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.208
H-Index - 33
ISSN - 2222-1808
DOI - 10.1016/s2222-1808(11)60006-6
Subject(s) - lipid profile , cd8 , medicine , human immunodeficiency virus (hiv) , cholesterol , antiretroviral therapy , lymphocyte , immunology , blood lipids , total cholesterol , lipid metabolism , cd4 cd8 ratio , gastroenterology , viral load , endocrinology , lymphocyte subsets , immune system
Objective: To assess lipid profile in patients with HIV positive infection and to correlate the\udvariation in lipid profile with the CD4+ and CD8+ cell count and establish the relationship between\udthe variables. Methods: Ninety-one participants were enrolled for the present study of which\udforty seven patients were HIV positive patients and forty four were controls. The study was carried\udout at College of Medicine & JNM Hospital, Kalyani. Ten mL of blood samples were collected from\udthe participants. The CD4 and CD8 lymphocyte count was estimated by Fluoresence Activated\udCell Sorter (FACS) count system (Becton Dickinson). Lipid profiles were analyzed enzymatically\udusing kit obtained from Randox Laboratories Limited, Crumlin, UK. Results: The changes in total\udcholesterol (TC), HDL-C, TC/HDL-C and age were not significant when compared between cases\udand controls. Significantly higher levels of triglycerides, low-density lipoprotein-cholesterol\ud(LDL-C), LDL /HDL-C, TG/HDL-C and CD4/CD8 ratio were observed along with decline in CD-4\udcells/毺 L, CD-8 cells/毺 L (P=0.0001). Furthermore there was a strong correlation between CD-4\udcells/毺 L and TG, LDL-C. Also triglycerides and LDL-C level increased proportional to the\udincrease in CD-4 cells/毺 L. Conclusions: It can be concluded that the changes in lipid profile\udcan be a good index of disease progression in HIV infection