Open AccessThe acute effect of the antioxidant drug “U-74389G” on red blood cells levels during hypoxia reoxygenation injury in rats
Author(s) -
Constantinos Tsompos,
Constantinos Panoulis,
Konstantinos Toutouzas,
George Zografos,
Αpostolos Papalois
Publication year - 2014
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(14)60068-8
Subject(s) - medicine , hypoxia (environmental) , antioxidant , drug administration , red blood cell , pharmacology , drug , antioxidant capacity , anesthesia , oxygen , biochemistry , oxidative stress , biology , chemistry , organic chemistry
ObjectiveTo examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a hypoxia reoxygenation (HR) protocol. The beneficial effect or non-effectiveness of that molecule was studied hematologically using mean red blood cells levels.Methods40 rats of mean weight 231.875 g were used in the study. Red blood cells levels were measured 60 min after reoxygenation (groups A and C) and 120 min after reoxygenation (groups B and D) with administration of the drug U-74389G only in groups C and D.ResultsU-74389G administration non-significantly increased the red blood cells level by (0.64±0.32)% (P=0.810 6). Reoxygenation time also non-significantly increased the red blood cells level by (4.63±2.36)% (P=0.068 0). However, U-74389G administration and reoxygenation time together non-significantly increased the red blood cells level by (1.05±0.53)% (P=0.491 1).ConclusionsResults of this study show that U-74389G administration, reoxygenation time and their interaction non significantly increased the red blood cells levels within 2 hours' time interval