Open AccessAntihyperglycemic and antihyperlipidemic properties of aqueous root extract of Icacina senegalensis in alloxan induced diabetic rats
Author(s) -
Godwin Christian Akuodor,
Pius Monday Udia,
Augustine Ini Lawrence Bassey,
Kingsley Chimsorom Chilaka,
OA Okezie
Publication year - 2014
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(14)60025-1
Subject(s) - alloxan , medicine , traditional medicine , aqueous extract , diabetes mellitus , pharmacology , endocrinology
Objective: To evaluate the antidiabetic and hypolipidemic activity of aqueous root extract of Icacina senegalensis (I. senegalensis) in alloxan-induced diabetic rats.Method: Blood glucose levels of alloxan-induced diabetic rats were monitored after the administration of I. senegalensis extract (100, 200 and 400 mg/kg) to diabetic rats for 14 d. Different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also examined.Results: Treatment of alloxan diabetic rats with the extract showed significant (P<0.05) activity. The activity of the extract was comparable to that of the standard drug, glinbeclamide.Conclusions: The results suggest that the root extract of I. senegalensis possesses antidiabetic and hypolipidemic properties, which might be a potential source for isolation of new orally active agent in the treatment of diabetes and its associated complications