Open AccessEvaluation of anticonvulsant activity of hydroalcoholic extract of Mussaenda philippica on animals
Author(s) -
DM Kar,
Rout Sk,
Laxmidhar Moharana,
Susruta Majumdar
Publication year - 2014
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(14)60010-x
Subject(s) - picrotoxin , strychnine , anticonvulsant , medicine , epilepsy , pharmacology , convulsion , traditional medicine , anesthesia , antagonist , psychiatry , receptor
ObjectiveTo evaluate the anticonvulsant activity of hydroalcoholic extracts of leaves and sepals of Mussaenda philippica (M. Philippica) and its fractions (methanol, dioxin and aqueous) against pentylene tetrazole (PTZ), maximal electroshock (MES), Strychnine (STR), Picrotoxin induced convulsions at different dose levels.MethodsThe anticonvulsant effect of extracts was studied by the MES, PTZ, STR and Picrotoxin-induced seizure.ResultsThe extract at 100 and 200 mg/kg, produced a significant (P <0.01) dose dependent increase in onset of convulsion compared to the control in MES, PTZ, strychnine and picrotoxin-induced seizures.ConclustionsThe data obtained indicates that Hydroalcoholic extracts of M. philippica leaves and sepals may help to control grandmal and petitmal epilepsy