Open AccessStudy of hepatic histomorphology in HBeAg+ and HBeAg− patients with CHB: Experience from Bangladesh
Author(s) -
Ayub Al Mamun,
. Mamun-Al-Mahtab,
Sheikh Mohammad Fazle Akbar,
Kutub Uddin Mollick,
Arun Jyoti Tarafdar,
Faiz Ahmad Khondokar,
Ahmed Lutful Mubin,
Mohammad Zashim Uddin,
Salimur Rahman
Publication year - 2013
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(13)60133-x
Subject(s) - medicine , hbeag , mutant , wild type , virology , promoter , core (optical fiber) , gastroenterology , hepatitis b virus , virus , gene , hbsag , biology , biochemistry , gene expression , materials science , composite material
ObjectiveTo compare Knodell and HAI scores in patients with wild type and pre-core/core promoter mutant CHB to see if there is any difference in severity of liver injury between these two types of HBV.MethodsWe did percutaneous liver biopsies of 155 CHB patients. Of them 102 (65.8%) were infected wild type HBV and the rest 53 (34.2%) were infected with pre-core/core promoter mutant CHB.Results11/53 (20.8%) patients with pre-core/core promoter mutant CHB had moderate to severe CH (HAI score 8-18). In contrast, moderate to severe CH was seen in 19/102 (18.6%) patients with wild type CHB. Fibrosis score was >2 in 15/53 (28.3%) pre-core/core promoter mutant CHB as opposed to 20/102 (19.6%) patients with wild type CHB.ConclusionsThe study shows that pre-core/core promoter mutant HBV produces more severe histological liver disease compared to wild type HBV