Open AccessChemomodulatory effects of Ichnocarpus frutescens R. Br against 4-vinylcyclohexane induced ovarian cancer in swiss albino mice
Author(s) -
Thangarajan Starlin,
Sathiyanathan Perumal,
Arul Raj Chinthamony,
Paramasivam Ragavendran,
Vidya Balasubramanian,
Sunitha Martin,
V. K. Gopalakrishnan
Publication year - 2013
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(13)60117-1
Subject(s) - medicine , ovarian cancer , histopathology , lipid peroxidation , creatinine , cancer , uric acid , enzyme , ovary , endocrinology , pathology , biochemistry , biology , oxidative stress
ObjectiveTo evaluate the protective effect of Ichnocarpus frutescens (I. frutescens) R. Br against 4-vinylcyclohexane induced ovarian cancer in Swiss albino mice.MethodsThe ovarian cancer was induced by 4-vinylcyclohexane which was given to 28-day-old mice in corn oil, intra peritoneally, at 2.7 mmol/kg body weight/day for 30 d. After that serum and tissue were isolated. Enzymatic antioxidants, non-enzymatic antioxidants, lipid peroxidation assessed in liver and ovary homogenate. Metabolites, marker enzymes were analyzed in serum. Tissue was examined histopathology examination.ResultsThe levels of urea, creatinine, marker enzymes and lipid peroxidation were significantly increased in ovarian cancer induced mice when compared to control group whereas, levels of uric acid, enzymatic and non-enzymatic antioxidants were decreased in cancer induced mice when compared with control mice. From these parameters were brought back to near normal in ethanolic extract of I. frutescens treated animals. The above results were further confirmed by histopathological examination which shows marked edema of lamina propria occurred in cancer induced animals whereas no alterations in ethanolic extract of I. frutescens and cisplatin treated groups.ConclusionsThis present study was evaluated that the ethanolic extracts of I. frutescens have effective anticancer activity against 4-vinylcyclohexane induced ovarian cancer