Open AccessFormulation and evaluation of antipsoriatic gel using natural excipients
Author(s) -
Raghupatruni Jhansi Laxmi,
Ramadoss Karthikeyan,
P. Srinivasa Babu,
R. Ganesh Babu
Publication year - 2013
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(13)60110-9
Subject(s) - psoralen , xanthan gum , chromatography , drug , dialysis tubing , medicine , pharmacology , chemistry , biochemistry , membrane , materials science , dna , rheology , composite material
AbstractObjectiveTo develop topical gel formulations of Psoralen using natural excipients to minimize the side effects of synthetic drugs.MethodsThe Psoralen gel formulations were prepared using different natural gums and polymers. The physicochemical compatibility between Psoralen and other excipients was confirmed by using Fourier transform infrared spectroscopy. All prepared gel formulations were evaluated for drug content uniformity, viscosity, pH, and stability. The release of psoralen from all formulations using dialysis membrane into a phosphate buffer pH 6.8 at 37°C was studied. Drug release from the formulations fitted best to the Higuchi model. From the drug release data the best formulation was optimized and the biological studies on albino mice were performed.ResultsPsoralen gel containing egg albumin and xanthan gum shows better incorporation of the drug. The drug activity was found to be 43.3%. Anti-psoriatic drug enhances the orthokeratotic cell differentiation in the epidermal scales.ConclusionsIn vitro anti-psoriatic activity of F3 showed the significant orthokeratosis in the mouse tail test when compared to control thus indicating that the formulation is effective in treating psoriasis