Open AccessDendritic nanocomposite for delivery of antibacterial agent
Author(s) -
Pureti Madhu Kumar,
P. Srinivasa Babu,
Shaik Rasheed,
Ramadoss Karthikeyan
Publication year - 2013
Publication title -
journal of acute disease
Language(s) - English
Resource type - Journals
eISSN - 2589-5516
pISSN - 2221-6189
DOI - 10.1016/s2221-6189(13)60092-x
Subject(s) - dendrimer , antibacterial activity , agar diffusion test , drug delivery , klebsiella pneumoniae , medicine , combinatorial chemistry , trimethoprim , microbiology and biotechnology , bacteria , nanotechnology , chemistry , antibiotics , organic chemistry , materials science , biology , biochemistry , escherichia coli , genetics , gene
ObjectiveTo develop and explore the use of PEGylated poly (propylene imine) dendritic architecture for the delivery of an anti bacterial bioactive, Trimethoprim.MethodsFor this study, PEGylated poly(propylene imine) dendritic architecture was synthesized and loaded with Trimethoprim and targeted to the resistant producing strains of both gram positive and gram negative. The antibacterial activity was carried out by agar well-diffusion method to compare zone of inhibition with standard drug and plain PPI dendrimer.ResultsThe study showed that the Trimethoprim loaded dendrimer has significant antibacterial activity than the plain PPI dendrimer, but standard drug was not shown zone of inhibition upon both microorganisms but Klebsiella pneumoniae (K. pneumoniae) the pure drug showed activity.ConclusionsIn this study antibacterial activity of synthesized system is also relatively safer and holds potential to deliver any other antibacterial agent to the resistant producing strains