Open AccessAn Aggressive Strategy for Maintenance of Sinus Rhythm Including a Combination of Catheter Ablation and Antiarrhythmic Drug Therapy Benefits Patients with Chronic Atrial Fibrillation
Author(s) -
Haruna Tetsuya,
Ikeguchi Shigeru,
Takeda Shinsaku,
Amaya Naoki,
Hata Tatsuhiko,
Okada Masaharu,
Kosuga Kunihiko
Publication year - 2009
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/s1880-4276(09)80018-5
Subject(s) - medicine , sinus rhythm , cardiology , atrial fibrillation , ablation , catheter ablation , pulmonary vein , anesthesia
The effects of restoration and maintenance of sinus rhythm by a combination of catheter ablation and antiarrhythmic drugs (AADs) on atrial function in patients with chronic atrial fibrillation (AF) remain unknown. In 15 patients with chronic AF (>1 year), we attempted to restore and maintain sinus rhythm by ablation targeting complex fractionated atrial electrocardiograms (CFAEs) combined with pulmonary vein isolation with or without AADs. Sinus rhythm was restored in all patients. At 17:7 ± 7:2 months after AF ablation, maintenance of sinus rhythm was achieved in 20% of patients without AADs and in 73.3% of patients with AADs. The left atrial diameter decreased significantly by 9:5 ± 8:1% (P < 0:05) during the 12‐month followup. AADs did not have any adverse effects. The aggressive strategy for maintenance of sinus rhythm involving AF ablation and AADs potentially led to recovery of structural changes in the LA in patients with chronic AF.