Open AccessTwo Cases of Pilsicainide Intoxication showing the Brugada‐type Electrocardiographic Findings and Incessant Wide QRS Tachycardia
Author(s) -
Sumiyoshi Masataka,
Hayashi Hidemori,
Ichinose Tetsuo,
Itoh Seigo,
Kawamura Masaki,
Suwa Satoru,
Sakurai Hidehiko
Publication year - 2008
Publication title -
journal of arrhythmia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 21
eISSN - 1883-2148
pISSN - 1880-4276
DOI - 10.1016/s1880-4276(08)80032-4
Subject(s) - medicine , cardiology , ventricular tachycardia , intraventricular conduction , qrs complex , anesthesia , tachycardia , brugada syndrome , electrocardiography
We have experienced two patients with the Brugada‐type electrocardiographic abnormalities and incessant wide QRS tachycardia (presumed ventricular tachycardia) induced by intoxication of a class IC antiarrhythmic drug pilsicainide. They were elderly men with impaired renal function. Plasma concentration of pilsicainide was elevated to a toxic level in both patients. After cessation of pilsicainide, incessant wide QRS tachycardia spontaneously subsided and intraventricular conduction delay with coved type ST segment elevation in V1 and V2 disappeared. In the elderly or patients with renal dysfunction, we should be very careful regarding dose adjustment of pilsicainide or it may be better to avoid using this drug.